Three-Dimensional Mapping of Optimal Left Ventricular Pacing Site for Cardiac Resynchronization

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Three-dimensional mapping of optimal left ventricular pacing site for cardiac resynchronization.

BACKGROUND The efficacy of cardiac resynchronization therapy (CRT) depends on placement of the left ventricular lead within the late-activated territory. The geographic extent and 3-dimensional distribution of left ventricular (LV) locations yielding optimal CRT remain unknown. METHODS AND RESULTS Normal or tachypacing-induced failing canine hearts made dyssynchronous by right ventricular fre...

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Single site left ventricular pacing for cardiac resynchronization.

Chronic, dilated heart failure is often accompanied by delayed ventricular electrical activation manifested as prolonged QRS duration, most commonly in the form of left bundle branch block (LBBB). Exploration of the link between the sequence of cardiac electrical activation and mechanical function is one of the most exciting contemporary areas of research in heart failure, but recognition of th...

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Alternative techniques for left ventricular pacing in cardiac resynchronization therapy.

Cardiac resynchronization therapy (CRT) is an important treatment modality for a well-defined subgroup of heart failure patients. Coronary sinus (CS) lead placement is the first-line clinical approach but the insertion is unsuccessful in about 5-10% of the patients. In recent years, the number of CRT recipients and the considerable need for left ventricular (LV) lead revisions increased enormou...

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ALternate Site Cardiac ResYNChronization (ALSYNC): a prospective and multicentre study of left ventricular endocardial pacing for cardiac resynchronization therapy.

AIMS The ALternate Site Cardiac ResYNChronization (ALSYNC) study evaluated the feasibility and safety of left ventricular endocardial pacing (LVEP) using a market-released pacing lead implanted via a single pectoral access by a novel atrial transseptal lead delivery system. METHODS AND RESULTS ALSYNC was a prospective clinical investigation with a minimum of 12-month follow-up in 18 centres o...

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Optimal left ventricular endocardial pacing sites for cardiac resynchronization therapy in patients with ischemic cardiomyopathy.

OBJECTIVES We sought to investigate the impact of left ventricular (LV) pacing site on mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy (ICM). BACKGROUND CRT reduces morbidity and mortality in patients with dyssynchronous LV failure; however, variability in response, particularly in ICM patients, poses ongoing challenges. Endocardial bive...

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ژورنال

عنوان ژورنال: Circulation

سال: 2007

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circulationaha.106.643718